This course will examine six of the worst environmental disasters caused by human error or other reasons. The historical background, causes, the health and environmental effects, the legal responsibility to victims, and consequences and regulatory changes of each disaster will be discussed. The first lecture will be an introduction to the discipline of toxicology, using examples of different toxins from these disasters and the Love Canal, NY disaster. The remaining lectures will each include an in-depth presentation of the details of each disaster. The following major disasters will be covered in chronological order: Minamata Bay, Japan; Seveso, Italy; Bhopal, India; Deepwater Horizon, USA.